Selective deficits in the sense of smell caused by chemical modification of the olfactory epithelium

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Science  30 Nov 1984:
Vol. 226, Issue 4678, pp. 1092-1094
DOI: 10.1126/science.6494927


A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins is demonstrated in vitro. In vivo studies show that the same procedure produces a selective anosmia ("odor blindness") when applied to the olfactory epithelia of experimental animals. Surgical experiments confirm that the sense of smell is specifically affected.

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