Synapsin I in nerve terminals: selective association with small synaptic vesicles

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Science  07 Dec 1984:
Vol. 226, Issue 4679, pp. 1209-1211
DOI: 10.1126/science.6438799


Immunocytochemistry revealed that synapsin I is preferentially (and possibly exclusively) associated with small (40- to 60-nanometer) synaptic vesicles and not with large (greater than 60-nanometer) dense-core vesicles in bovine hypothalamus. These observations may explain why synapsin I is found exclusively in neurons, since small synaptic vesicles are specific to neurons whereas large dense-core vesicles in neurons may be considered the equivalent of secretory organelles in endocrine cells.

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