Persistence of the entire Epstein-Barr virus genome integrated into human lymphocyte DNA

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Science  14 Dec 1984:
Vol. 226, Issue 4680, pp. 1322-1325
DOI: 10.1126/science.6095452


The entire Epstein-Barr virus genome is integrated into Burkitt tumor cell DNA at the terminal direct repeat sequence of the virus. There is no homology between the GC-rich (G, guanine; C, cytosine) terminal repeat and the AT-rich (A, adenine; T, thymine) cell sequences with which it has recombined. More than 15 kilobases of cell DNA have been deleted and 236 base pairs are duplicated at one virus-cell junction site.