Uromodulin: a unique 85-kilodalton immunosuppressive glycoprotein isolated from urine of pregnant women

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Science  02 Aug 1985:
Vol. 229, Issue 4712, pp. 479-481
DOI: 10.1126/science.2409603


Crude fractions of urine from pregnant women are immunosuppressive in vitro. An 85-kilodalton immunosuppressive glycoprotein purified to homogeneity from such urine inhibited in vitro assays of human T-cell and monocyte activity at concentrations of 10(-9) to 10(-11) molar. This material was nontoxic and blocked early events required for normal T-cell proliferation in vitro. On the basis of its tissue source and its in vitro activity, the name "uromodulin" is proposed for this glycoprotein.

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