Androgens prevent normally occurring cell death in a sexually dimorphic spinal nucleus

See allHide authors and affiliations

Science  16 Aug 1985:
Vol. 229, Issue 4714, pp. 671-673
DOI: 10.1126/science.4023706


The spinal nucleus of the bulbocavernosus (SNB) contains many more motoneurons in adult male rats than in females. Androgens establish this sex difference during a critical perinatal period, which coincides with normally occurring cell death in the SNB region. Sex differences in SNB motoneuron number arise primarily because motoneuron loss is greater in females than in males during the early postnatal period. Perinatal androgen treatment in females attenuates cell death in the SNB region, reducing motoneuron loss to levels typical of males. The results suggest that steroid hormones determine sex differences in neuron number by regulating normally occurring cell death and that the timing of this cell death may therefore define critical periods for steroid effects on neuron number.

Stay Connected to Science