Noninvasive study of high-energy phosphate metabolism in human heart by depth-resolved 31P NMR spectroscopy

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Science  23 Aug 1985:
Vol. 229, Issue 4715, pp. 769-772
DOI: 10.1126/science.4023711


Phosphorus-31 nuclear magnetic resonance (NMR) spectra showing the relative concentrations of high-energy phosphate metabolites have been recorded noninvasively from the human heart in vivo. Spectral data were spatially localized by combining a pulsed magnetic field gradient with surface NMR excitation-detection coils. The location of the selected spectral region was determined by conventional proton NMR imaging immediately before examination by phosphorus-31 NMR spectroscopy.

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