Defining lipid transport pathways in animal cells

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Science  13 Sep 1985:
Vol. 229, Issue 4718, pp. 1051-1057
DOI: 10.1126/science.4035344


A new technique for studying the metabolism and intracellular transport of lipid molecules in living cells based on the use of fluorescent lipid analogs is described. The cellular processing of various intermediates (phosphatidic acid and ceramide) and end products (phosphatidylcholine and phosphatidylethanolamine) in lipid biosynthesis is reviewed and a working model for compartmentalization during lipid biosynthesis is presented.

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