Systemic ethanol: selective enhancement of responses to acetylcholine and somatostatin in hippocampus

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Science  10 Jan 1986:
Vol. 231, Issue 4734, pp. 161-163
DOI: 10.1126/science.2867600


In rat hippocampal pyramidal cells tested in situ by iontophoresis of several neurotransmitters, ethanol significantly enhanced excitatory responses to acetylcholine and inhibitory responses to somatostatin-14 but had no statistically significant effect on excitatory responses to glutamate or inhibitory responses to gamma-aminobutyric acid or, in preliminary tests, to norepinephrine or serotonin. The effects of ethanol on responses to acetylcholine and somatostatin-14 may provide insight into synaptic mechanisms underlying the behavioral consequences of ethanol intoxication.

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