Alterations of myc, myb, and rasHa proto-oncogenes in cancers are frequent and show clinical correlation

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Science  17 Jan 1986:
Vol. 231, Issue 4735, pp. 261-265
DOI: 10.1126/science.3941898


Alterations of c-myc, c-rasHa, or c-myb oncogenes were found in more than one-third of human solid tumors. Amplification of c-myc occurred in advanced, widespread tumors or in aggressive primary tumors. Apparent allelic deletions of c-rasHa and c-myb can be correlated with progression and metastasis of carcinomas and sarcomas.

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