Crystal structure analysis of deamino-oxytocin: conformational flexibility and receptor binding

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Science  02 May 1986:
Vol. 232, Issue 4750, pp. 633-636
DOI: 10.1126/science.3008332


Two crystal structures of deamino-oxytocin have been determined at better than 1.1A resolution from isomorphous replacement and anomalous scattering x-ray measurements. In each of two crystal forms there are two closely related conformers with disulfide bridges of different chirality, which may be important in receptor recognition and activation.