Estrogen-induced factors of breast cancer cells partially replace estrogen to promote tumor growth

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Science  20 Jun 1986:
Vol. 232, Issue 4757, pp. 1540-1543
DOI: 10.1126/science.3715461


The hormone 17 beta-estradiol acts through its receptor system to induce MCF-7 human breast cancer cells to form tumors in athymic mice. In vitro studies have identified the production of estrogen-induced growth factors from MCF-7 cells that may have a role in growth control. These induced growth factors were sufficient to stimulate MCF-7 tumor growth in ovariectomized athymic mice, thus partially replacing estradiol. Growth factors may act as estrogen-induced "second messengers" in estrogen-responsive growth of human breast cancer.

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