Participation of c-myc protein in DNA synthesis of human cells

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Science  24 Oct 1986:
Vol. 234, Issue 4775, pp. 467-470
DOI: 10.1126/science.3532322


The protein product of oncogene c-myc is believed to be important in regulation of the cell cycle. However, its direct role in DNA synthesis has not been explored. Experiments presented here show that the addition of affinity-purified antibodies against the human c-myc protein to nuclei isolated from several types of human cells reversibly inhibited DNA synthesis and DNA polymerase activity of these nuclei. This suggests that c-myc encodes a protein that is functionally involved in DNA synthesis.

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