24 April 1987
Vol 236, Issue 4800

About The Cover

The smallest gold-conjugated antibody label yet developed is demonstrated in this pseudocolored electron micrograph. Anti-ferritin Fab' antibody fragments are covalently linked to 11 gold atom clusters (yellow spots, discerned by high pass filtration) and attached to ferritin, which consists of a protein shell surrounding an iron core (red) (×7,100,000). See page 450. [J. F. Hainfeld; image analysis by P. S. Furcinitti; photo by M. Rosen, Brookhaven National Laboratory, Upton, NY 11973]