24 July 1987
Vol 237, Issue 4813

About The Cover

Fragile X-bearing somatic cell hybrids cultured under positive selection for hypoxanthine guanine phosphoribosyl transferase (HGPRT) followed by in situ histochemical staining for glucose-6-phosphate dehydrogenase (G6PD) activity. The G6PD+ (blue) and G6PD- (yellow) colonies indicate segregation of the HGPRT and G6PD genes, suggesting chromosome breakage at the fragile X site. See page 420. [Photo by S. T. Warren, Emory University School of Medicine, Atlanta, GA 30322]