Blockade of "NMDA" receptors disrupts experience-dependent plasticity of kitten striate cortex

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Science  16 Oct 1987:
Vol. 238, Issue 4825, pp. 355-358
DOI: 10.1126/science.2443978


Intracortical infusion of the "N-methyl-D-aspartate" (NMDA) receptor blocker D,L-2-amino-5-phosphonovaleric acid (APV) renders kitten striate cortex resistant to the effects of monocular deprivation. In addition, 1 week of continuous APV treatment (50 nanomoles per hour) produces a striking loss of orientation selectivity in area 17. These data support the hypothesis that crucial variables for the expression of activity-dependent synaptic modifications are a critical level of postsynaptic activation and calcium entry through ion channels linked to NMDA receptors.

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