Development of the primary antibody repertoire

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Science  20 Nov 1987:
Vol. 238, Issue 4830, pp. 1079-1087
DOI: 10.1126/science.3317825


The ability to generate a diverse immune response depends on the somatic assembly of genes that encode the antigen-binding portions of immunoglobulin molecules. In this article, we discuss the mechanism and control of these genomic rearrangement events and how aspects of this process are involved in generating the primary antibody repertoire.

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