Redesigning nature's poisons to create anti-tumor reagents

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Science  20 Nov 1987:
Vol. 238, Issue 4830, pp. 1098-1104
DOI: 10.1126/science.3317828


Immunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.

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