Signal for attachment of a phospholipid membrane anchor in decay accelerating factor

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Science  27 Nov 1987:
Vol. 238, Issue 4831, pp. 1280-1283
DOI: 10.1126/science.2446389


Decay accelerating factor (DAF) belongs to a novel group of membrane proteins anchored to the cell surface by a glycophospholipid membrane anchor that is covalently attached to the carboxyl terminus of the protein. The last 37 amino acids of membrane DAF, when fused to the carboxyl terminus of a secreted protein, are sufficient to target the fusion protein to the plasma membrane by means of a glycophospholipid anchor. This approach provides a novel means of targeting proteins to the cell-surface membrane.