The gene for familial polyposis coli maps to the long arm of chromosome 5

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Science  04 Dec 1987:
Vol. 238, Issue 4832, pp. 1411-1413
DOI: 10.1126/science.3479843


The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.

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