Antagonistic adrenergic-muscarinic regulation of M current in smooth muscle cells

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Science  08 Jan 1988:
Vol. 239, Issue 4836, pp. 190-193
DOI: 10.1126/science.2827305


The beta-adrenergic agonist isoproterenol and analogs of adenosine 3',5'-monophosphate (cAMP) induced a potassium current, M current, in freshly dissociated gastric smooth muscle cells. Muscarinic agonists suppress this current, apparently by acting at a locus downstream from regulation of cAMP levels by adenylate cyclase and phosphodiesterase. Thus, M current can be induced by an agent and regulated in antagonistic fashion by beta-adrenergic and muscarinic systems.

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