Cell and environment interactions in tumor microregions: the multicell spheroid model

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Science  08 Apr 1988:
Vol. 240, Issue 4849, pp. 177-184
DOI: 10.1126/science.2451290


Abnormal vascularization of malignant tumors is associated with the development of microregions of heterogeneous cells and environments. Experimental models such as multicell spheroids and a variety of new techniques are being used to determine the characteristics of these microregions and to study the interactions of the cells and microenvironments. The special cellular microecology of tumors influences responsiveness to therapeutic agents and has implications for future directions in cancer research.

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