Identification and characterization of a neuron-specific nuclear antigen in Drosophila

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Science  13 May 1988:
Vol. 240, Issue 4854, pp. 913-916
DOI: 10.1126/science.3129785


An antigen found only in neuronal nuclei of Drosophila melanogaster is revealed by staining with a monoclonal antibody (Mab44C11). This antigen appears early in development, before neurons show any other signs of antigenic or morphologic differentiation, and persists throughout development. This nuclear staining permits reliable detection of neurons in developmental studies of wild-type and mutant flies. Protein immunoblot analyses and immune precipitation experiments show that the neuronal nuclear antigen is a 50-kilodalton polypeptide.

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