Light-addressable potentiometric sensor for biochemical systems

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Science  27 May 1988:
Vol. 240, Issue 4856, pp. 1182-1185
DOI: 10.1126/science.3375810


Numerous biochemical reactions can be measured potentiometrically through changes in pH, redox potential, or transmembrane potential. An alternating photocurrent through an electrolyte-insulator-semiconductor interface provides a highly sensitive means to measure such potential changes. A spatially selectable photoresponse permits the determination of a multiplicity of chemical events with a single semiconductor device.

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