Inhibition of cellular proliferation by antisense oligodeoxynucleotides to PCNA cyclin

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Science  10 Jun 1988:
Vol. 240, Issue 4858, pp. 1544-1546
DOI: 10.1126/science.2897717


The proliferating cell nuclear antigen (PCNA or cyclin) is a nuclear protein recently identified as a cofactor of DNA polymerase delta. When exponentially growing Balb/c3T3 cells are exposed to antisense oligodeoxynucleotides to PCNA, both DNA synthesis and mitosis are completely suppressed. A corresponding sense oligodeoxynucleotide has no inhibitory effects. These experiments indicate that PCNA (cyclin) is important in cellular DNA synthesis and in cell cycle progression.