The coupling of neurotransmitter receptors to ion channels in the brain

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Science  29 Jul 1988:
Vol. 241, Issue 4865, pp. 545-551
DOI: 10.1126/science.2456612


Recent studies on the action of neurotransmitters on hippocampal pyramidal cells indicate that different neurotransmitter receptors that use either the same or different coupling mechanisms converge onto the same ion channel. Conversely, virtually all of the neurotransmitters act on at least two distinct receptor subtypes coupled to different ion channels on the same cell. The existence of both convergence and divergence in the action of neurotransmitters results in a remarkable diversity in neuronal signaling.

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