23 September 1988
Vol 241, Issue 4873

About The Cover

Photomicrograph of a cultured rat sensory neuron 24 hours after infection with pHSViac, a defective herpes simplex virus 1 (HSV-1) vector that expresses Escherichia coli -galactosidase (blue, X-gal reaction product). HSV-1 vectors have the potential to introduce any gene into a neuron to perform gene therapy or study neuronal physiology. See page 1667. [Alfred I. Geller, Massachusetts General Hospital, Boston, MA 02114]