Research Articles

The SCID-hu mouse: murine model for the analysis of human hematolymphoid differentiation and function

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Science  23 Sep 1988:
Vol. 241, Issue 4873, pp. 1632-1639
DOI: 10.1126/science.2971269


The study of human hematopoietic cells and the human immune system is hampered by the lack of a suitable experimental model. Experimental data are presented showing that human fetal liver hematopoietic cells, human fetal thymus, and human fetal lymph node support the differentiation of mature human T cells and B cells after engraftment into mice with genetically determined severe combined immunodeficiency. The resultant SCID-hu mice are found to have a transient wave of human CD4+ and CD8+ T cells and human IgG (immunoglobulin G) in the peripheral circulation. The functional status of the human immune system within this mouse model is not yet known.

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