Induction of B cell unresponsiveness to noninherited maternal HLA antigens during fetal life

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Science  30 Sep 1988:
Vol. 241, Issue 4874, pp. 1815-1817
DOI: 10.1126/science.3051377


Patients who have received many transfusions become highly sensitized and develop antibodies against almost all HLA alloantigens, so that finding a cross-match negative kidney donor is difficult. A survey of those patients showed that 50 percent did not form antibodies against the noninherited maternal HLA antigens. Apart from the obvious clinical implications, the data indicate that a human equivalent of murine neonatal or actively acquired tolerance has now been identified.