Cellular and molecular mechanisms of drug dependence

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Science  04 Nov 1988:
Vol. 242, Issue 4879, pp. 715-723
DOI: 10.1126/science.2903550


The molecular and cellular actions of three classes of abused drugs--opiates, psychostimulants, and ethanol--are reviewed in the context of behavioral studies of drug dependence. The immediate effects of drugs are compared to those observed after long-term exposure. A neurobiological basis for drug dependence is proposed from the linkage between the cellular and behavioral effects of these drugs.

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