Frame-shift deletions in patients with Duchenne and Becker muscular dystrophy

See allHide authors and affiliations

Science  04 Nov 1988:
Vol. 242, Issue 4879, pp. 755-759
DOI: 10.1126/science.3055295


Duchenne muscular dystrophy (DMD) and its less severe form Becker muscular dystrophy (BMD) are allelic disorders. It has been suggested that in the mutations involving BMD, the translational reading frame of messenger RNA is maintained and a smaller, though partially functional, protein is produced. In order to test this, the exon-intron boundaries of the first ten exons of the DMD gene were determined, and 29 patients were analyzed. In a number of BMD patients (mild and severe BMD), the reading frame of messenger RNA was not maintained. On the basis of these findings, a model for reinitiation from an internal start codon is suggested.

Stay Connected to Science