Cloning of a membrane protein that induces a slow voltage-gated potassium current

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Science  18 Nov 1988:
Vol. 242, Issue 4881, pp. 1042-1045
DOI: 10.1126/science.3194754


A rat kidney messenger RNA that induces a slowly activating, voltage-dependent potassium current on its expression in Xenopus oocytes was identified by combining molecular cloning with an electrophysiological assay. The cloned complementary DNA encodes a novel membrane protein that consists of 130 amino acids with a single putative transmembrane domain. This protein differs from the known ion channel proteins but is involved in the induction of selective permeation of potassium ions by membrane depolarization.

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