Innovative approaches to plasminogen activator therapy

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Science  06 Jan 1989:
Vol. 243, Issue 4887, pp. 51-56
DOI: 10.1126/science.2492113


Plasminogen activator therapy for acute myocardial infarction has become standard medical practice. Bleeding complications, however, limit the utility of the currently available agents. This article reviews how the tools of molecular biology and protein engineering are being used to develop safer and more effective plasminogen activators.

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