A novel vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis

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Science  13 Jan 1989:
Vol. 243, Issue 4888, pp. 212-214
DOI: 10.1126/science.2783496


Salivary gland lysates of the sand fly Lutzomyia longipalpis contain a potent vasodilator that aids the fly to feed on the blood of its vertebrate hosts. Chromatographic analysis, antibody reactivity, and data obtained from bioassays of the salivary erythema-inducing factor indicate striking similarity with human calcitonin gene-related peptide. The erythema-inducing factor is, however, at least one order of magnitude more potent than calcitonin gene-related peptide.

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