ReportsArticles

AIDS-Kaposi's sarcoma-derived cells express cytokines with autocrine and paracrine growth effects

See allHide authors and affiliations

Science  13 Jan 1989:
Vol. 243, Issue 4888, pp. 223-226
DOI: 10.1126/science.2643161

Abstract

When grown in vitro, cells from Kaposi's sarcoma lesions of AIDS patients (AIDS-KS cells) constitutively release several growth promoting activities. When inoculated into nude mice, the AIDS-KS cells induce a KS-like lesion of mouse origin. Here it is shown that the AIDS-KS cells express messenger RNA for a complex mixture of cytokines that correlate with several of the biological activities of these cells. Basic fibroblast growth factor, which is a potent angiogenic factor, and interleukin-1 messenger RNAs are expressed at very high levels and seem to account for a large proportion of the activities, since their corresponding proteins are released in biologically active form into the culture media where they induce autocrine and paracrine growth effects.

Stay Connected to Science