A yeast actin-binding protein is encoded by SAC6, a gene found by suppression of an actin mutation

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Science  13 Jan 1989:
Vol. 243, Issue 4888, pp. 231-233
DOI: 10.1126/science.2643162


The protein encoded by SAC6, a gene that can mutate to suppress a temperature-sensitive defect in the yeast actin gene, has been identified as a 67-kilodalton actin-binding protein (ABP 67) that associates with all identifiable actin structures. This finding demonstrates the in vivo functional importance of the actin-ABP 67 interaction previously established in vitro and illustrates the use of suppressor analysis to identify physically interacting proteins.