A Salmonella locus that controls resistance to microbicidal proteins from phagocytic cells

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Science  24 Feb 1989:
Vol. 243, Issue 4894, pp. 1059-1062
DOI: 10.1126/science.2646710


Facultative intracellular pathogens pose an important health problem because they circumvent a primary defense mechanism of the host: killing and degradation by professional phagocytic cells. A gene of the intracellular pathogen Salmonella typhimurium that is required for virulence and intracellular survival was identified and shown to have a role in resistance to defensins and possibly to other microbicidal mechanisms of the phagocyte. This gene may prove to be a regulatory element in the expression of virulence functions.

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