Reduction of intestinal carcinogen absorption by carcinogen-specific secretory immunity

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Science  17 Mar 1989:
Vol. 243, Issue 4897, pp. 1462-1464
DOI: 10.1126/science.2928780


A secretory immune response to the carcinogen 2-acetylaminofluorene (AAF) was elicited in rabbits by directly immunizing the small intestine with an AAF-cholera toxin conjugate. High-titer, high-affinity secretory immunoglobulin A (IgA) antibody to AAF was secreted into the intestinal lumen in response to this immunogen. Immune secretions reduced the transepithelial absorption of a 125I-labeled derivative of AAF by more than half. This reduction of absorption by hapten-specific IgA suggests that oral vaccines against carcinogens and toxicants could be developed for humans.

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