The EGF receptor kinase substrate p35 in the floor plate of the embryonic rat CNS

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Science  17 Mar 1989:
Vol. 243, Issue 4897, pp. 1477-1479
DOI: 10.1126/science.2928781


P35 is a calcium- and phospholipid-binding protein that was originally isolated as a substrate for the epidermal growth factor (EGF) receptor tyrosine kinase and later was found to be related to lipocortin I. Immunohistochemistry was used to localize p35 to a raphe of primitive glial ependymal cells in the median one-third of the floor plate in the central nervous system (CNS) of rat embryos. The p35 appears by embryonic day 12 before the arrival of pioneering ventral commissural axons. The unexpected, discrete distribution of this protein during development opens the question of its role in neural morphogenesis.

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