Scanning tunneling microscopy of uncoated recA-DNA complexes

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Science  31 Mar 1989:
Vol. 243, Issue 4899, pp. 1708-1711
DOI: 10.1126/science.2928803


Uncoated recA-DNA complexes were imaged with the scanning tunneling microscope (STM). The images, which reveal the right-handed helical structure of the complexes with subunits clearly resolved, are comparable in quality to STM images of metal-coated specimens. Possible conduction mechanisms that allow STM imaging of biological macromolecules are discussed.

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