Template-directed oligomerization catalyzed by a polynucleotide analog

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Science  21 Apr 1989:
Vol. 244, Issue 4902, pp. 329-331
DOI: 10.1126/science.2540527


A pyrophosphate-linked analog of polycytidylic acid has been synthesized and shown to catalyze the oligomerization of the complementary monomer 2'-deoxyguanosine 3',5'-bisphosphoimidazolide. Analogs of polynucleotides are of interest in studies of the origins of life as possible precursors of the first RNA molecules. These results demonstrate that such molecules are capable of serving as templates for further synthesis.

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