Research Articles

Catalytic antibodies with lipase activity and R or S substrate selectivity

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Science  28 Apr 1989:
Vol. 244, Issue 4903, pp. 437-440
DOI: 10.1126/science.2717936


The specific hydrolysis of unactivated esters bearing an R or S enantiomeric alcohol has been achieved by two separate classes of catalytic antibodies induced to bind either the R or S substrates. The antibodies exhibit rate accelerations (10(3) to 10(5] above background hydrolysis that, coupled with their antipodal specificity, provide a novel set of reagents for use in synthesis.

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