Control of experimental autoimmune encephalomyelitis by T cells responding to activated T cells

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Science  19 May 1989:
Vol. 244, Issue 4906, pp. 820-822
DOI: 10.1126/science.2471264


T cell vaccination against experimental autoimmune disease is herein shown to be mediated in part by anti-ergotypic T cells, T cells that recognize and respond to the state of activation of other T cells. The anti-ergotypic response thus combines with the previously shown anti-idiotypic T cell response to regulate autoimmunity.

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