Dictyostelium discoideum: a model system for cell-cell interactions in development

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Science  08 Sep 1989:
Vol. 245, Issue 4922, pp. 1054-1058
DOI: 10.1126/science.2672337


The cellular slime mold Dictyostelium discoideum undergoes a transition from single-celled amoebae to a multicellular organism as a natural part of its life cycle. A method of cell-cell signaling that controls chemotaxis, morphogenesis, and gene expression has developed in this organism, and a detailed understanding of this signaling system provides clues to mechanisms of intercellular communication in the development of metazoans.

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