Contragestion and other clinical applications of RU 486, an antiprogesterone at the receptor

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Science  22 Sep 1989:
Vol. 245, Issue 4924, pp. 1351-1357
DOI: 10.1126/science.2781282


RU 486, a steroid with high affinity for the progesterone receptor, is the first available active antiprogesterone. It has been used successfully as a medical alternative for early pregnancy interruption, and it also has other potential applications in medicine and for biochemical and pathophysiological endocrine research.

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