Mechanism of insect resistance to the microbial insecticide Bacillus thuringiensis

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Science  05 Jan 1990:
Vol. 247, Issue 4938, pp. 72-74
DOI: 10.1126/science.2294593


Receptor binding studies show that resistance of a laboratory-selected Plodia interpunctella strain to a Bacillus thuringiensis insecticidal crystal protein (ICP) is correlated with a 50-fold reduction in affinity of the membrane receptor for this protein. The strain is sensitive to a second type of ICP that apparently recognizes a different receptor. Understanding the mechanism of resistance will provide strategies to prevent or delay resistance and hence prolong the usefulness of B. thuringiensis ICPs as environmentally safe insecticides.

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