Prenylated proteins: the structure of the isoprenoid group

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Science  19 Jan 1990:
Vol. 247, Issue 4940, pp. 318-320
DOI: 10.1126/science.2296720


The mevalonate-derived portion of a prenylated protein from Chinese hamster ovary cells has been established as diterpenoid (C20). This group is linked to a carboxyl-terminal cysteine as a thioether. It was removed from the protein by hydrazinolysis followed by Raney nickel desulfurization, and the resulting hydrocarbon fraction was analyzed by gas chromatography-mass spectrometry.

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