Microinjection of a conserved peptide sequence of p34cdc2 induces a Ca2+ transient in oocytes

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Science  19 Jan 1990:
Vol. 247, Issue 4940, pp. 327-329
DOI: 10.1126/science.2153316


The product of the yeast cell cycle control gene cdc2, and its homologs in higher eukaryotes (p34cdc2), all contain a perfectly conserved sequence of 16 amino acids that has not been found in any other protein sequence. Microinjection of this peptide triggers a specific increase in the concentration of intracellular free Ca2+ that originates from intracellular stores in both starfish and Xenopus oocytes. Thus, p34cdc2 might interact through its conserved peptide domain with some component of the Ca2(+)-regulatory system.

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