Two distinct transcription factors that bind the immunoglobulin enhancer microE5/kappa 2 motif

See allHide authors and affiliations

Science  26 Jan 1990:
Vol. 247, Issue 4941, pp. 467-470
DOI: 10.1126/science.2105528


Activity of the immunoglobulin heavy and kappa light chain gene enhancers depends on a complex interplay of ubiquitous and developmentally regulated proteins. Two complementary DNAs were isolated that encode proteins, denoted ITF-1 and ITF-2, that are expressed in a variety of cell types and bind the microE5/kappa 2 motif found in both heavy and kappa light chain enhancers. The complementary DNAs are the products of distinct genes, yet both ITF-1 and ITF-2 are structurally and functionally similar. The two proteins interact with one another through their putative helix-loop-helix motifs and each possesses a distinct domain that dictates transcription activation.

Stay Connected to Science