Protein sorting to mitochondria: evolutionary conservations of folding and assembly

See allHide authors and affiliations

Science  23 Feb 1990:
Vol. 247, Issue 4945, pp. 930-938
DOI: 10.1126/science.2406905


According to the endosymbiont hypothesis, mitochondria have lost the autonomy of their prokaryotic ancestors. They have to import most of their proteins from the cytosol because the mitochondrial genome codes for only a small percentage of the polypeptides that reside in the organelle. Recent findings show that the sorting of proteins into the mitochondrial subcompartments and their folding and assembly follow principles already developed in prokaryotes. The components involved may have structural and functional equivalents in bacteria.

Stay Connected to Science