HTLV-I trans-activator protein, tax, is a trans-repressor of the human beta-polymerase gene

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Science  02 Mar 1990:
Vol. 247, Issue 4946, pp. 1082-1084
DOI: 10.1126/science.2309119


Human T cell leukemia virus type I (HTLV-I) is the etiological agent for adult T cell leukemia (ATL). The HTLV-I trans-activator protein Tax can activate the expression of its own long terminal repeat (LTR) and many cellular and viral genes. Tax down-regulated the expression of human beta-polymerase (hu beta-pol), a cellular enzyme involved in host cell DNA repair. This finding suggests a possible correlation between HTLV-I infection and host chromosomal damage, which is often seen in ATL cells.

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